French neurologist, Jean-Baptiste Landry had patients who developed weakness and paralysis within the legs, arms, neck, and breathing muscles within the chest cavity, in 1859.
1891 Quinke demonstrated a spinal fluid removal
Cerebrospinal fluid (CSF) findings were first established by Jean-Baptiste Landry in 1859 and then again established by Jean Alexander Barré in 1916
1916 Georges Guillain, Jean Alexander Barré and Andre Strohl, found characteristics of abnormality in GBS; increased spinal fluid protein with normal cell count
First part of Landry’s discovery was the sensory signs and symptoms
Tingling and numbness followed within toes and fingers
Upper body improving first followed by strength in the legs (acute ascending paralysis)
Can affect any peripheral nerves (nerves outside of the brain and spinal cord); motor nerves (carries information to the muscles and glands), sensory nerves (carries information from body, to spinal cord to brain), and autonomic nerves (regulates bodily functions; heart rate, and digestion)
GBS usually only occurs once; to have any additional episodes is rare
Damage to the myelin sheath covering the peripheral nerves
GBS was clinically established in the early 1900’s.