Background


Background
  • French neurologist, Jean-Baptiste Landry had patients who developed weakness and paralysis within the legs, arms, neck, and breathing muscles within the chest cavity, in 1859.
  • 1891 Quinke demonstrated a spinal fluid removal
  • Cerebrospinal fluid (CSF) findings were first established by Jean-Baptiste Landry in 1859 and then again established by Jean Alexander Barré in 1916
  • 1916 Georges Guillain, Jean Alexander Barré and Andre Strohl, found characteristics of abnormality in GBS; increased spinal fluid protein with normal cell count
  • First part of Landry’s discovery was the sensory signs and symptoms
  • Tingling and numbness followed within toes and fingers
  • Upper body improving first followed by strength in the legs (acute ascending paralysis)
  • Can affect any peripheral nerves (nerves outside of the brain and spinal cord); motor nerves (carries information to the muscles and glands), sensory nerves (carries information from body, to spinal cord to brain), and autonomic nerves (regulates bodily functions; heart rate, and digestion)
  • GBS usually only occurs once; to have any additional episodes is rare
  • Damage to the myelin sheath covering the peripheral nerves
  • GBS was clinically established in the early 1900’s.