· Acute Inflammatory Demyelinating polyneuropathy (AIDP)
o Most commonly called GBS
o Immune system attacking the myelin sheath (covering of nerves)
o The damaging of the myelin sheath (covering of nerves) leads to symmetrical (both sides) weakness and sensory(brain to body info) loss or changes; tingling and numbness
· Acute Motor Axonal Neuropathy (AMAN)
o Similar to AIDP
o Rapid onset, symmetrical (both sides) paralysis, without any sensory (brain to body info) changes
o Nerve damage occurs at areas of exposed axons (part of the nerve cell that conducts impulses)
· Acute Motor Sensory Axonal Neuropathy (AMSAN)
o Severe form of GBS that develops over days
o Paralysis and sensory loss due to axonal (part of the nerve cell that conducts impulses) damage
o Often triggered by food poisoning
· Miller Fisher Syndrome (Slow onset)
o Can be demyelinating or axonal
o Double vision from weak eye muscles
o Wobbly walk; loss of balance
o Loss of deep tendon reflexes
o Injury to the nerves controlling the eye muscles causes weakness so the eyes can’t move together; double vision
o Blurred vision caused by paralysis of pupillary function (lack of pupil constriction)
o Weakness of limbs, facial paralysis, and difficulty swallowing; overlapping with features of GBS
o Individuals with GBS can have ocular muscle weakness and double vision.
· Chronic Inflammatory demyelinating Polyneuropathy (CIDP)
o It is closely related to GBS
o Progressive symmetrical weakness and sensory loss within the legs and arms that can develop slowly or quickly over an 8 week period. Weakness occurs on both sides of the body and is not self-limiting.
· Multifocal Motor Neuropathy (MMN)
o Rare, chronic, progressive neuropathy
o Predominantly distal (farthest away from center), asymmetric (one side) limb weakness; mostly upper limbs
o The hands, forearms, feet, and legs are more affected than the shoulders and hips.
o One side is more affected than the other side.
· Multifocal Acquired Demyelinating Sensory and Motor Neuropathy (MADSAM)
o Rare form of CIDP
o Shares MMN features; asymmetric (one side) weakness, but has sensory (brain to body info) changes; tingling or loss of sensation within the damaged nerves